Pharmacology

• Fluoroquinolone Antibiotic (see Fluoroquinolones, [[Fluoroquinolones]])

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Adverse Effects

Cardiac Adverse Effects

• Q-T Prolongation/Torsade (see Torsade, [[Torsade]])
  • Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
  • Risk of Q-T Prolongation (in descending order or probability)
    • High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
    • Medium: Gemifloxacin, Levofloxacin, Ofloxacin
    • Low: Ciprofloxacin
  • Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small

Orthopedic Adverse Effects

• Tendinitis/Tendon Rupture (see xxx)

Other Adverse Effects

• xxxxx

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References

• xxx