Moxifloxacin (Avelox, Avalox, Avelon)

Pharmacology


Adverse Effects

Cardiac Adverse Effects

  • Q-T Prolongation/Torsade (see Torsade, [[Torsade]])
    • Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
    • Risk of Q-T Prolongation (in descending order or probability)
      • High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
      • Medium: Gemifloxacin, Levofloxacin, Ofloxacin
      • Low: Ciprofloxacin
    • Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small

Orthopedic Adverse Effects

  • Tendinitis/Tendon Rupture (see xxx)

Other Adverse Effects

  • xxxxx

References

  • xxx