Minocycline

Indications

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Pharmacology


Administration

  • PO

Adverse Effects

Dermatologic Adverse Effects

Gastrointestinal/Hepatic Adverse Effects

  • Acute Pancreatitis (see Acute Pancreatitis, [[Acute Pancreatitis]]): definite association with acute pancreatitis
  • Hepatitis
    • Hepatic steatosis: may lead to liver failure
    • Autoimmune hepatitis: ANA positive (84% of cases)
    • xxx

Hematologic Adverse Effects

  • Serum Sickness-Like-Reaction (see Serum Sickness, [[Serum Sickness]])

Pulmonary Adverse Effects

Lung Nodule (see Lung Nodule or Mass, [[Lung Nodule or Mass]])

Drug-Induced Pulmonary Eosinophilia (see Drug-Induced Pulmonary Eosinophilia, [[Drug-Induced Pulmonary Eosinophilia]])

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS Syndrome) (see Drug Rash with Eosinophilia and Systemic Symptoms, [[Drug Rash with Eosinophilia and Systemic Symptoms]])

Hypersensitivity Pneumonitis (see Hypersensitivity Pneumonitis, [[Hypersensitivity Pneumonitis]])

Renal Adverse Effects

Acute Interstitial Nephritis (see Acute Interstitial Nephritis, [[Acute Interstitial Nephritis]])

  • Physiology: class effect common to all tetracyclines

Rheumatologic Adverse Effects

  • Drug-Induced Systemic Lupus Erythematosus (SLE) (see Systemic Lupus Erythematosus, [[Systemic Lupus Erythematosus]])
    • Epidemiology: low-moderate risk
    • Diagnosis
      • Positive p-ANCA (Lawson, 2001 study): may be seen
  • Vasculitis (see Vasculitis, [[Vasculitis]])

References

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