Midodrine

Indications

Hypotension (see Hypotension, [[Hypotension]])

  • End-Stage Liver Disease (see End-Stage Liver Disease, [[End-Stage Liver Disease]])
  • Sepsis (see Sepsis, [[Sepsis]])
    • Trial of Midodrine During Recovery Phase in Septic Shock (Chest, 2016) [MEDLINE]: midodrine decreases pressor use during the recovery phase of sepsis and may be associated with decreased ICU length of stay

Hepatorenal Syndrome (see Hepatorenal Syndrome, [[Hepatorenal Syndrome]])

  • xxxx

Pharmacology

  • Vasoconstriction

Metabolism

  • xxx

Administration

  • PO: 10 mg TID

Dose Adjustment

  • Hepatic
  • Renal

Adverse Effects

Cardiovascular Adverse Effects

  • QT Prolongation without Definite Association with Torsade (see Torsade, [[Torsade]])

Other Adverse Effects

  • xxx

References

  • Feasibility, utility, and safety of midodrine during recovery phase from septic shock. Chest. 2016 Mar 4. pii: S0012-3692(16)41575-8. doi: 10.1016/j.chest.2016.02.657 [MEDLINE]