Micafungin (Mycamine)

Indications

  • Candidemia (see Candida, [[Candida]])
  • Candida Esophagitis (see Candida, [[Candida]])
  • Candida Peritonitis/Abscess (see Candida, [[Candida]])
  • Candida Prophylaxis (see Candida, [[Candida]])

Pharmacology

  • Echinocandin (see Echinocandins, [[Echinocandins]])
    • Concentration-dependent inhibition of 1,3-beta-D-glucan synthase -> decreased synthesis of 1,3-beta-D-glucan (an essential polysaccharide in the Candida cell wall) -> osmotic instability -> cellular lysis
  • Origin/Synthesis: micafungin is a natural antifungal derived from the lipopeptide FR901379, isolated from the Coleophoma empetri fungus
  • Metabolism: hepatic

Administration

  • IV (Candidemia/Candida Peritonitis/Candida Abscess): 100 mg qday
  • IV (Candida Esophagitis): 150 mg qday
  • IV (Candida Prophylaxis): 50 mg qday

Adverse Effects

Gastrointestinal Adverse Effects

Hematologic Adverse Effects

Other Adverse Effects

  • Headache (see Headache, [[Headache]])
  • Rash/Pruritus

References

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