Mafenide Acetate (Sulfamylon)

Epidemiology

Topical Antibiotic Used in Burn Patients to Prevent Bacterial Colonization Prior to Skin Grafting (see Burns, [[Burns]])
- Mafenide is Rapidly Absorbed Systemically

Pharmacology

Sulfonamide Antibiotic with Carbonic Anhydrase Inhibition Properties (see Sulfonamides, [[Sulfonamides]]): some of its metabolites also have carbonic anhydrase inhibition properties
- Renal Bicarbonate Loss: bicarbonate is replaced by chloride (produces hyperchloremia)

Metabolism

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Administration

TOPICAL: xxx

Dose Adjustment

Hepatic
Renal

Adverse Effects

Renal Adverse Effects

Type 2 Proximal Renal Tubular Acidosis with Non-Anion Gap Metabolic Acidosis (NAGMA) (see Type 2 Proximal Renal Tubular Acidosis, [[Type 2 Proximal Renal Tubular Acidosis]]) and Metabolic Acidosis-Normal Anion Gap, [[Metabolic Acidosis-Normal Anion Gap]])

Other Adverse Effects

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References

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