Levofloxacin (Levaquin)

Indications

  • xxx

Pharmacology


Administration

  • PO:
  • IV:

Adverse Effects

Pulmonary Adverse Effects

Cardiac Adverse Effects

  • Q-T Prolongation (see Torsade, [[Torsade]])
  • Dose-dependently block cardiac voltage-gated potassium channels -> delay in cardiac repolarization
    • Risk of Q-T Prolongation (in descending order or probability)
      • High: Sparfloxacin, Grepafloxacin, Moxifloxacin, Gatifloxacin
      • Medium: Gemifloxacin, Levofloxacin, Ofloxacin
      • Low: Ciprofloxacin
    • Risk of Q-T prolongation with fluoroquinolones is mainly related to additive effects with other Q-T prolonging drugs, risk when used alone is small

Hematologic Adverse Effects

Orthopedic Adverse Effects


References

  • Levofloxacin-induced autoimmune hemolytic anemia. Ann Pharmacother. 2003 Jul-Aug;37(7-8):1010-3 [MEDLINE]