Lepirudin (Refludan)

General Information

  • Bayer ceased production in 2012

Indications


Pharmacology

  • Thrombin Inhibitor (see Factor IIa Inhibitors, [[Factor IIa Inhibitors]])
  • Half-Life: 40 min
  • Metabolism: renal -> use with caution in renal insufficiency
    • Development of Anti-Hirudin Antibodies: occurs in 44% of cases
    • Monitor PTT

Administration

  • xxxx

Adverse Effects

Hematologic Adverse Effects

  • Hemorrhage

Other Adverse Effects

  • xxx

References

  • xxxx