Labetalol (Normodyne, Trandate)

Indications


Contraindications

Bradycardia (Bradycardia, [[Bradycardia]])

  • Labetalol May Exacerbate Bradycardia

Atrioventricular Heart Blocks

Hypotension (see Hypotension, [[Hypotension]])

  • Labetalol May Exacerbate Hypotension

Pharmacology

Metabolism

  • Hepatic: extensive (via CYP450)

Half-Life

  • Half-Life: 5-8 hrs

Excretion

  • Feces: 50%
  • Renal: 50%

Administration

  • PO: start 100 mg BID, escalate in increments of 200 mg per day every 2-3 days (max 2400 mg/day)
    • May divide dose TID instead
  • IV Drip: 2 mg/min (max dose: 300 mg)

Dose Adjustment

  • Hepatic: use with caution in liver disease
  • Renal: none

Adverse Effects

Allergic Adverse Effects

  • Anaphylactoid Reaction (see Anaphylaxis, [[Anaphylaxis]])

Cardiovascular Adverse Effects

Atrioventricular Heart Blocks

Bradycardia (see Bradycardia, [[Bradycardia]])

  • xxx

Congestive Heart Failure (CHF) (see Congestive Heart Failure, [[Congestive Heart Failure]])

  • xxx

Hypotension (see Hypotension, [[Hypotension]])

  • xxxx

Syncope (see Syncope, [[Syncope]])

  • xxx

Gastrointestinal/Hepatic Adverse Effects

Neurologic Adverse Effects

Otolaryngologic Adverse Effetcts

Pulmonary Adverse Effects

Renal Adverse Effects

  • Elevated Blood Urea Nitrogen (BUN) and Creatinine (Cr)

Rheumatologic Adverse Effects

Other Adverse Effects

  • Ejaculatory Dysfunction
  • Intraoperative Floppy Iris Syndrome

Adverse Effects with Abrupt Discontinuation


References

  • xxx