Isoproterenol (Isoprenaline, Isuprel, Medihaler-Iso)

Indications

  • Symptomatic Bradycardia (see xxxx, [[xxxx]])

Pharmacology

  • β1-Adrenergic Receptor Agonist (see β1-Adrenergic Receptor Agonists, [[β1-Adrenergic Receptor Agonists]])
    • Positive Chronotropy with Increase in Blood Pressure) -> increased cardiac output
    • Positive Inotropy (with Increase in Blood Pressure) -> increased cardiac output
  • β2-Adrenergic Receptor Agonist (see β2-Adrenergic Receptor Agonists, [[β2-Adrenergic Receptor Agonists]])
    • Bronchodilation
    • Vasodilation (with Decrease in Diastolic Blood Pressure): via effects on β2-adrenergic-receptors in arteriolar smooth muscle
  • TAAR1 Agonist: effects at this receptor resemble those of trace amines (such as tyramine)

Pharmacodynamics

  • Plasma Half-Life: 2 min

Metabolism

  • xxxx

Administration

  • IV: 2-10 ug/min
  • PO:
  • INH:

Dose Adjustment

  • Hepatic:
  • Renal:

Risk of Extravasation-Associated Tissue Damage

  • Tissue Necrosis

Adverse Effects

Cardiovascular Adverse Effects

Other Adverse Effects

  • xxx
  • xxx
  • xxx

References

  • xxxx