Isoniazid (INH, Laniazid, Nydrazid)

Pharmacology

  • Variation in the N-acetyltransferase gene (NAT2) divides people into “slow acetylators” and “fast acetylators,” with very different half-lives and blood concentrations of important drugs such as isoniazid

Adverse Effects

Pulmonary Adverse Effects

Hepatic Adverse Effects

  • Hepatotoxicity

Rheum Adverse Effects

Hematologic Adverse Effects

  • Sideroblastic Anemia (see Anemia)

References

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