Interferon Gamma-1b (Actimmune)

Indications

  • Idiopathic Pulmonary Fibrosis (IPF) (see Idiopathic Pulmonary Fibrosis, [[Idiopathic Pulmonary Fibrosis]]): studies demonstrate no clinical benefit
  • Non-Small Lung Cancer (see Lung Cancer, [[Lung Cancer]])

Pharmacology


Administration

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Adverse Effects

Pulmonary Adverse Effects

  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
    • Epidemiology: case reports with use in IPF
    • Treatment/Prognosis: unresponsive to steroids and fatal in 3 cases
  • Increased Risk of Radiation Pneumonitis (see Radiation Pneumonitis and Fibrosis, [[Radiation Pneumonitis and Fibrosis]])
    • Epidemiology: reported to occur with combination XRT + Interferon Gamma therapy in the treatment of non-small cell lung cancer

Other Adverse Effects

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References

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