Folate

History

  • Food and Drug Administration (FDA) Mandate (1998): the FDA began requiring manufacturers to add folate to enriched breads, cereals, flours, cornmeals, pastas, rice, and other grain products
    • As cereals and grains are widely consumed in the US, these products have become very important contributors of folate to the American diet
    • The food folate fortification program was initially projected to increase folate intake in the US by approximately 100 mcg/day, but the program actually increased mean folate intake to about 190 mcg/day

Folate Physiology

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Folate Deficiency

Etiology

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Clinical Manifestations

Hematologic Manifestations

Other Manifestations

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Treatment

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References

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