Ethacrynic Acid (Edecrin)

Indications


Pharmacology

  • Npn-Sulfonamide Loop Diuretic: inhibition of sodium-potassium-chloride cotransport in the ascending loop of Henle
    • Unlike the other loop diuretics, ethacrynic acid is not a sulfonamide (therefore, Its use is not contraindicated with sulfa allergy)
  • Inhibition of Glutathione S-Transferases: due to ethacrynic acid itself and its glutathione adduct
    • Glutathione S-transferases are involved in xenobiotic metabolism

Administration

  • PO:
  • IV:

Adverse Effects

Renal Adverse Effects

Other Adverse Effects

  • Increased Risk of Gastric Hemorrhage Associated with Corticosteroid Treatment
  • Ototoxicity with Reversible/Permanent Hearing Loss: more commonly occurs in patients with severe renal impairment
    • May also increase the ototoxicity of other drugs, such as aminoglycosides and cephalosporins

References

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