Indications

• Hypertension (see Hypertension, [[Hypertension]])
  • Aortic Dissection (see Aortic Dissection, [[Aortic Dissection]])
  • Hypertensive Emergency (see Hypertension, [[Hypertension]])
• Rate Control of Supraventricular Arrhythmias
  • Atrial Fibrillation (see Atrial Fibrillation, [[Atrial Fibrillation]])
  • Supraventricular Tachycardia (see Supraventricular Tachycardia, [[Supraventricular Tachycardia]])

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Pharmacology

• Cardioselective (β1-Selective) β-Adrenergic Receptor Antagonist (see β-Adrenergic Receptor Antagonists, [[β-Adrenergic Receptor Antagonists]])

Metabolism

• xxx

Half-Life

• Half-Life: xxx

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Administration

• IV: load 1000 mcg/kg IVP over 30 sec, then drip 150-300 mcg/kg/min
  • Taper dose gradually to discontinue

Dose Adjustment

• Hepatic: undefined
• Renal
  • Elevated metabolite levels in end-stage renal disease
  • Not dialyzable

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Adverse Effects

Cardiovascular Adverse Effects

• Bradycardia (see Bradycardia, [[Bradycardia]])
• Hypotension (see Hypotension, [[Hypotension]])

Pulmonary Adverse Effects

• Bronchospasm/Exacerbation of Obstructive Airways Disease (see Obstructive Lung Disease, [[Obstructive Lung Disease]])

Other Adverse Effects

• xxx
• xxx
• xxx

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References

• xxx