Dronedarone (Multaq)

Indications


Pharmacology

  • xxx

Metabolism

  • xxx

Administration

  • PO: xxx

Dose Adjustment

  • Hepatic
  • Renal

Drug Interactions

  • Digoxin (see Digoxin, [[Digoxin]]): dronedarone increases digoxin levels (via P-glycoprotein interaction)
    • Permanent Atrial Fibrillation Outcome Study Using Dronedarone On Top Of Standard Therapy (PALLAS) Trial (2015) [MEDLINE]: dronedarone is associated with both increased cardiovascular death and heart failure in patients with permanent atrial fibrillation
      • There was a strong effect of concurrent digoxin use on the adverse effect of dronedarone on cardiovascular death (in patients on digoxin, there were 11 arrhythmic deaths on dronedarone and none on placebo; in patients not on digoxin, there were 2 arrhythmic deaths on dronedarone and 4 on placebo)
      • There was no interaction between baseline digoxin use and the adverse effect of dronedarone on heart failure events

Adverse Effects

Pulmonary Adverse Effects

Other Adverse Effects

  • xxxxx
  • xxxxx
  • xxxxx

References

  • Interaction between digoxin and dronedarone in the PALLAS trial. Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1019-25. doi: 10.1161/CIRCEP.114.002046. Epub 2014 Nov 6 [MEDLINE]