Dopamine Receptor Antagonists

Agents

Phenothiazines

  • Chlorpromazine (Largactil, Thorazine) (see Chlorpromazine, [[Chlorpromazine]])
  • Prochlorperazine (Compazine) (see Prochlorperazine, [[Prochlorperazine]])
  • Promethazine (Phenergan) (see Promethazine, [[Promethazine]]): phenothiazine derivative

Butryophenones

  • Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar) (see Droperidol, [[Droperidol]])
  • Haloperidol (Haldol) (see Haloperidol, [[Haloperidol]])

Benzamides

  • Domperidone (Motilium) (see Domperidone, [[Domperidone]])
  • Metoclopramide (Reglan) (see Metoclopramide, [[Metoclopramide]])
    • Low Dose: central and peripheral dopamine D2 receptor antagonism
    • High Dose: weak 5HT3 antagonism
    • Enhances acetylcholine release and stimulates cholinergic receptors on gastric smooth muscle
  • Trimethobenzamide

Atypical Anti-Psychotics (Also Exhibit Serotonergic Antagonism)

  • Clozapine (Clozaril) (see Clozapine, [[Clozapine]])
  • Olanzapine (Zyprexa) (see Olanzapine, [[Olanzapine]])
  • Quetiapine (Seroquel) (see Quetiapine, [[Quetiapine]])
  • Risperidone (Risperdal) (see Risperidone, [[Risperidone]])
  • Ziprasidone (Geodon) (see Ziprasidone, [[Ziprasidone]])

Tricyclic Antidepressants


Contraindications


References

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