Docetaxel (Taxotere)

Indications


Pharmacology

  • Taxane (see Taxanes, [[Taxanes]]): taxanes are diterpenes produced by the plants of the genus Taxus (yews)
    • Docetaxel (Taxotere)
    • Paclitaxel (Taxol) (see Paclitaxel, [[Paclitaxel]])

Administration

  • IV

Adverse Effects

Acute or Subacute Interstitial Pneumonitis (see Interstitial Lung Disease-Etiology, [[Interstitial Lung Disease-Etiology]])

  • Epidemiology: increased risk of lung toxicity when used in combination with Gemcitabine (see Gemcitabine, [[Gemcitabine]])
  • Treatment: responsive to corticosteroids (see Corticosteroids, [[Corticosteroids]])

Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])

  • Clinical: xxx

Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]])

  • Clinical: xxx

Diffuse Alveolar Hemorrhage (see Diffuse Alveolar Hemorrhage, [[Diffuse Alveolar Hemorrhage]]): absence of pulmonary capillarities (bland alveolar hemorrhage)

  • Clinical: xxx

References

  • Docetaxel. J Clin Oncol 1995; 13: 2643-2655
  • Docetaxel and interstitial pulmonary injury. Ann Oncol 1997; 8: 191-194
  • Pneumopathie interstitielle diffuse aiguĂ« sous docetaxel (Taxotere). Rev Mal Respir 1998; 15: 199-203
  • Severe pulmonary toxicity in patients treated with combination of docetaxel and gemcitabine for metastatic transitional cell carcinoma. Ann Oncol 1999; 18: 943-947
  • Severe pulmonary toxicity in patients treated with a combination of docetaxel and gemcitabine for metastatic transitional cell carcinoma. Annals of Oncology 1999; 10: 943-947
  • Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics 2000; 5: 1245-1259
  • Chemotherapy-induced noncardiogenic pulmonary edema related to gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor support. Respiration 2000; 67: 680-3
  • Severe interstitial pneumonitis following high-dose cyclophosphamide, thiotepa and docetaxel: two case reports and a review of the literature. Bone Marrow Transplantation 2001; 27: 559-563
  • Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere). British Journal of Cancer 2001; 85: 1247-1250
  • Severe interstitial pneumonitis associated with docetaxel administration. Cancer 2002; 94: 847-853
  • High incidence of pulmonary toxicity of weekly docetaxel and gemcitabine in patients with non-small cell lung cancer: results of a dose-finding study. Lung Cancer; Volume 44, Issue 3, June 2004, Pages 363-368
  • Docetaxel-induced acute pulmonary capillary-leak syndrome mimicking cardiogenic oedema. Ann Fr Anesth Reanim 2007; 26: 180-1