Dextran

Indications

  • xxxx

Pharmacology

  • xxx

Administration

  • IV:

Adverse Effects

Pulmonary Adverse Effects

  • Acute Lung Injury-ARDS (see Acute Lung Injury-ARDS, [[Acute Lung Injury-ARDS]])
    • Epidemiology: associated with use of dextran during hysteroscopy
      • Hyskon is a low molecular weight dextran used mainly in hysteroscopic surgery (usually to treat infertility): endometrial cavity is usually distended with 500 mL of low molecular weight dextran
    • Risk Factors for Acute Lung Injury from Dextran Use During Hysteroscopy
      • Use of >500 mL Dextran
      • Excessive Irritation of Endometrial Surface
      • Procedure Length >45 min
  • Diffuse Alveolar Hemorrhage (DAH) (see Diffuse Alveolar Hemorrhage, [[Diffuse Alveolar Hemorrhage]]): absence of pulmonary capillaritis

Hematologic Adverse Effects

  • Acquired Von Willebrand Disease (see Von Willebrand Disease, [[Von Willebrand Disease]]): branched polysaccharides of 40 or 70 kDa which inhibit platelet factor-3 availability, adsorb to platelets, and decrease plasma factor VIII-VWF -> inhibit platelet aggregation + secretion

Other Adverse Effects

  • xxx

References

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