Dantrolene

Indications

  • Malignant Hyperthermia (see Malignant Hyperthermia, [[Malignant Hyperthermia]])
  • Spastic Neurologic Disorders

Pharmacology

  • Long-Acting Skeletal Muscle Relaxant: contains a hydantoin moiety
    • Inhibits release of calcium from muscle sarcoplasmic reticulum and antagonizes calcium effect on muscle contraction

Administration

  • IV: 2.5 mg/kg, repeat q5 min to max 10 mg/kg or until improvement, then maintenance q 5-8 hrs

Adverse Effects

Pulmonary Adverse Effects

  • Pleural Effusion (see Pleural Effusion-Exudate, [[Pleural Effusion-Exudate]])
    • Diagnosis
      • CBC: eosinophilia
      • Pleural Fluid: may have pleural eosinophilia

Cardiac Adverse Effects

Other Adverse Effects

  • xxx

References

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