Indications

• Chronic Kidney Disease (CKD) with Renal Osteodystrophy (see Chronic Kidney Disease, [[Chronic Kidney Disease]])

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Pharmacology

• Synthetic Vitamin D Analog, Which is the Hormonally Active Form of Vitamin D (see Vitamin D, [[Vitamin D]])
  • Calcitriol increases absorption of dietary calcium from the gastrointestinal tract -> increased serum calcium
  • Calcitriol increasing renal tubular reabsorption of calcium -> increased serum calcium
  • Calcitriol increases release of calcium from bone by its action on osteoblasts, causing them to release RANKL -> activation of osteoclasts -> increased serum calcium

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Adverse Effects

• Hypercalcemia (see Hypercalcemia, [[Hypercalcemia]])

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References

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