Azathioprine (Imuran)


  • Used to treat both neoplastic and non-neoplastic conditions

Dosing and Administration

  • PO: 2.5 mg/kg/day -> start at 50 mg/day (max: 200 mg/day)
    • Maximal effects may not be seen for 6-9 months
    • Better side effect profile than cyclophosphamide
    • May be used long-term
  • Monitor: LFT’s, CBC


  • Metabolized to 6-mercaptopurine (which is known to have pulmonary toxicity)

Adverse Effects

Pulmonary Adverse Effects

GI Adverse Adverse Effects

Hematologic Adverse Effects

  • Myelosuppression


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