Ammonium Chloride

Indications

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Pharmacology

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Ammonium chloride is a systemic and urinary acidifying agent that is converted to ammonia and hydrochloric acid through oxidation by the liver. Ammonium chloride is poorly tolerated due to adverse effects including encephalopathy, metabolic acidosis, and ammonia toxicity, which consists of diaphoresis, altered breathing, bradycardia, arrhythmias, and coma.6 Additionally, rapid IV infusion of ammonium chloride has been associated with central nervous system toxicity that includes mental confusion, irritability, seizures, and coma.

Metabolism

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Administration

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Dose Adjustment

  • Hepatic:
  • Renal:

Adverse Effects

Other Adverse Effects

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References

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