Allergen Immunotherapy

Indications

Allergic Asthma (see Asthma, [[Asthma]])

  • Clinical Efficacy
    • Systematic Review (88 Trials) of Injection Allergen Immunotherapy in Asthma (Cochrane Database Syst Rev, 2010) [MEDLINE]
      • Trials Used Multiple Allergens: House Dust Mites, Pollen, Animal Dander, Cladosporium Mold, and Latex
      • Allergen Immunotherapy Decreased Asthma Symptoms, Medication Use, and Airway Reactivity
      • Allergen Immunotherapy Had No Consistent Effect on Lung Function
      • Local or Systemic Adverse Effects (Anaphylaxis) Were Observed in Trials

Allergic Rhinitis (see Allergic Rhinitis, [[Allergic Rhinitis]])

  • Clinical Efficacy
    • Systematic Review of Sublingual Allergen Immunotherapy in Children and Adults (Allergy, 2011) [MEDLINE]
      • Sublingual Allergen Immunotherapy is Effective
      • No Episodes of Anaphylaxis Were Noted

Food Allergy (see Food Allergy, [[Food Allergy]])

  • Clinical Efficacy
    • xxxx
  • Recommendations: xxxx

Pharmacology

  • xxx

Adverse Effects

Allergic Adverse Effects

  • Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]])
    • Epidemiology: associated with subcutaneous allergen immunotherapy

Dermatologic Adverse Effects

  • Local Skin Site Reaction
    • Epidemiology: associated with subcutaneous allergen immunotherapy

References

  • Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD001186. doi: 10.1002/14651858.CD001186.pub2 [MEDLINE]
  • Systematic reviews of sublingual immunotherapy (SLIT). Allergy. 2011;66(6):740 [MEDLINE]