Alemtuzumab (Campath, MabCampath, Campath-1H, Lemtrada)

Indications

Transplantation

  • Acute Lung Transplant Rejection (Acute Cellular Lung Transplant Rejection) (see Acute Lung Transplant Rejection, [[Acute Lung Transplant Rejection]])
  • Conditioning for Bone Marrow Transplantation (see Bone Marrow Transplant, [[Bone Marrow Transplant]])
  • Conditioning for Renal Transplantation (see Renal Transplant, [[Renal Transplant]])
  • Conditioning for Islet Cell Transplantation

Other


Pharmacology

  • Anti-CD52 Monoclonal Antibody: binds to CD52 on mature lymphocytes, targeting them for destruction
    • However, does not bind to stem cells from which lymphocytes are derived

Metabolism

  • xxx

Administration

  • xxx

Dose Adjustment

  • Hepatic
  • Renal

Adverse Effects

Other Adverse Effects


References

  • xxx