α2-Adrenergic Receptor Agonists

Agents

  • 4-NEMD
  • 7-Me-Marsanidine (also I1 agonist)
  • Agmatine (also I agonist, NMDA, 5-HT3, nicotinic antagonist and NOS inhibitor)
  • Apraclonidine
  • Brimonidine
  • Cannabigerol (also acts as a moderate affinity 5-HT1A receptor agonist, and low affinity CB1 receptor antagonist)
  • Clonidine (Catapres, Kapvay, Nexiclon) (see Clonidine, [[Clonidine]])
  • Detomidine
  • Dexmedetomidine (Precedex) (see Dexmedetomidine, [[Dexmedetomidine]])
  • Epinephrine (see Epinephrine, [[Epinephrine]]): lesser affinity for α2-adrenergic receptor than norepinephrine
  • Fadolmidine
  • Guanabenz
  • Guanfacine
  • Lofexidine
  • Marsanidine
  • Medetomidine
  • Methamphetamine
  • Mivazerol
  • Norepinephrine (Levophed) (see Norepinephrine, [[Norepinephrine]]): greater affinity for α2-adrenergic receptor than epinephrine
  • Rilmenidine (also I agonist)
  • Romifidine
  • Talipexole (also dopamine agonist)
  • Tizanidine (Zanaflex) (see Tizanidine, [[Tizanidine]]): centrally acting
  • Tolonidine
  • Xylazine
  • Xylometazoline

Pharmacology

α2A-Adrenergic Receptor is Found in the Following Central Nervous System Regions

Brainstem (especially the locus coeruleus)
Midbrain
Hypothalamus
Hippocampus
Spinal cord
Cerebral cortex
Cerebellum
Septum

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α2B-Adrenergic Receptor is Found in the Following Central Nervous System Regions

Olfactory system
Thalamus
Pyramidal layer of the hippocampus
Cerebellar purkinje layer

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α2C-Adrenergic Receptor is Found in the Following Central Nervous System Regions

Midbrain
Thalamus
Amygdala
Dorsal root ganglia
Olfactory system
Hippocampus
Cerebral cortex
Basal ganglia
Substantia nigra
Ventral tegmentum

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References

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