Neuroleptic Malignant Syndrome (NMS)

Etiology

  • Atypical Anti-Psychotics
    • Olanzapine (Zyprexa) (see Olanzapine, [[Olanzapine]])
    • Quetiapine (Seroquel) (see Quetiapine, [[Quetiapine]])
    • Risperidone (Risperdal) (see Risperidone, [[Risperidone]])
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Physiology

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Clinical Manifestations

Cardiovascular Manifestations

  • Autonomic Instability
    • Arrhythmias
    • Irregular Blood Pressure
    • Irregular Heart Rate

Neurologic Manifestations

  • Altered Mental Status

Rheumatologic/Orthopedic Manifestations

  • Muscle Rigidity
  • Rhabdomyolysis (see Rhabdomyolysis, [[Rhabdomyolysis]])

Other Manifestations

  • Diaphoresis: due to autonomic instability
  • Fever/Hyperpyrexia (see Fever, [[Fever]])

Treatment

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References

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