More Commonly Occurs in Immunocompromised Host with or without Coexisting Pneumonia
Sinus Involvement May Occur Secondary to Hematogenous Dissemination
Physiology
In Immunocompromised Hosts, Angioinvasion is Common and Hematogenous Dissemination May Occur
Clinical
In Immunocompromised Hosts, Clinical Findings Mimic Those Seen in Aspergillus Sinusitis: including nasal discharge, nasal obstruction, mucosal necrosis, periorbital cellulitis, and paranasal cellulitis
More Commonly Occurs in Immunocompromised Host: lung involvement is common in invasive infection (with the lung involved in approximately 50% of cases)
In Immunocompromised Hosts, Lung Involvement May Be the Presenting Manifestation (i.e. Primary Lung Involvement) or May Become Infected Due to Hematogenous Dissemination (Often Bilaterally)
More Commonly Occurs in Immunocompromised Host: lung involvement is common in invasive infection (with the lung involved in approximately 50% of cases)
Fungemia Typically Occurs in the Setting of Disseminated Disease (Although Cases Originating from Central Venous Catheters May Manifest Fungemia without Organ Involvement)
Blood Cultures are Positive in Approximately 40% of Disseminated Fusarium Cases: due to the fact that Fusarium sporulates in vivo, facilitating hematogenous dissemination
Generalized Skin Lesions
Secondary Organ Involvement Due to Hematogenous Dissemination
Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev. 1994;7(4):479 [MEDLINE]
Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909 [MEDLINE]
Emerging fungi. Infect Dis Clin North Am. 2006;20(3):563 [MEDLINE]
Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 2007;20(4):695 [MEDLINE]
Fusariosis. Semin Respir Crit Care Med. 2015 Oct;36(5):706-14 [MEDLINE]