Burkholderia Cepacia Complex

Microbiology

  • Member of Burkholderia Genus (see Burkholderia, [[Burkholderia]])
    • Formerly Known as Pseudomonas Cepacia

Taxonomy of Burkholderia Cepacia Complex Species (and Frequency in Cystic Fibrosis Patients in the United States) (see Cystic Fibrosis, [[Cystic Fibrosis]]) (Curr Opin Pulm Med, 2005) [MEDLINE]

  • Burkholderia Cepacia (Genomovar I): 3% of cystic fibrosis patients
  • Burkholderia Multivorans (Genomovar II): 40% of cystic fibrosis patients
  • Burkholderia Cenocepacia (Genomovar III): 45% of cystic fibrosis patients
  • Burkholderia Stabilis (Genomovar IV): <1% of cystic fibrosis patients
  • Burkholderia Vietnamiensis (Genomovar V): 6% of cystic fibrosis patients
  • Burkholderia Dolosa (Genomovar VI): 4% of cystic fibrosis patients
  • Burkholderia Ambifaria (Genomovar VII): 1% of cystic fibrosis patients
  • Burkholderia Anthina (Genomovar VIII): <1% of cystic fibrosis patients
  • Burkholderia Pyrrocinia (Genomovar IX): <1% of cystic fibrosis patients
  • Indeterminate: 1% of cystic fibrosis patients

Epidemiology

Risk Factors


Clinical Manifestations

Pulmonary Manifestations

Pneumonia/Colonization in Cystic Fibrosis (see Cystic Fibrosis, [[Cystic Fibrosis]])

  • Epidemiology
    • xxxx
  • Clinical
    • xxxx

Poor Outcome After Lung Transplantation (see Lung Transplant, [[Lung Transplant]])

  • xxxx

Other Manifestations

  • Outbreak Related to Contaminated Liquid Docusate (see Docusate, [[Docusate]])
    • Epidemiology: reported in mechanically-ventilated patients (without cystic fibrosis)

Treatment


References

  • Centers for Disease Control and Prevention. Healthcare-assocated infection. Multistate outbreak of Burkholderia cepacia infections. https://www.cdc.gov/hai/outbreaks/b-cepacia/index.html
  • US Food and Drug Administration. Oral liquid docusate sodium by PharmaTech: Recall – contaminated with B. cepacia. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm511528.htm
  • Outcome of Burkholderia cepacia colonisation in an adult cystic fibrosis centre. Thorax 2002; 57:142—145 [MEDLINE]
  • Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation. Thorax 2004; 59:526—528 [MEDLINE]
  • Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults. J Cyst Fibros 2004; 3: 93—98 [MEDLINE]
  • Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax 2004; 59:948—951 [MEDLINE]
  • Update on the Burkholderia cepacia complex. Curr Opin Pulm Med. 2005 Nov;11(6):528-33 [MEDLINE]