Splenomegaly

Etiology

Inborn Error of Metabolism

  • Gaucher disease
  • Niemann-Pick Disease

Infection

  • Infectious Hepatitis
  • Cytomegalovirus
  • Malaria
  • Babesiosis

Lymphoproliferative/Myeloproliferative Disease

Hematologic Defects

Vascular congestion

Immunologic Disease


Clinical

Asymptomatic Splenomegaly

Hypersplenism

  • Physiology: splenic sequestration of one or more cell lines with destruction
  • Diagnosis: Extravascular Hemolysis
    • elevated retic count
    • Smear: immature WBC and platelets
    • BM Biopsy: normo-hypercellular marrow without evidence of impaired production
  • Clinical
  • Treatment: Treat underlying disease, Splenectomy

References

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