Iron Deficiency Anemia

Epidemiology

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Etiology

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Physiology

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Diagnosis

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Clinical Manifestations

Pulmonary Manifestations

  • Dyspnea (see Dyspnea, [[Dyspnea]])

Other Manifestations

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Treatment

Oral Iron

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Intravenous Iron

Agents

  • Ferumoxytol (Feraheme) (see Ferumoxytol, [[Ferumoxytol]])
    • Risk of First-Exposure Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]]) [MEDLINE]: 24 per 100k patients
  • Iron Dextran (Dexferrum, INFeD) (see Iron Dextran, [[Iron Dextran]])
    • Risk of First-Exposure Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]] [MEDLINE]): 68 per 100k patients
    • Cumulative Risk of Anaphylaxis (Over 12 wk Period) [MEDLINE]: iron dextrose has highest risk of all of the intravenous iron agents
  • Iron Gluconate (Ferrous Gluconate, Fergon, Ferralet, Simron) (see Iron Gluconate, [[Iron Gluconate]])
    • Risk of First-Exposure Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]]) [MEDLINE]: 24 per 100k patients
  • Iron Sucrose (Venofer) (see Iron Sucrose, [[Iron Sucrose]])
    • Risk of First-Exposure Anaphylaxis (see Anaphylaxis, [[Anaphylaxis]]) [MEDLINE]: 24 per 100k patients
    • Cumulative Risk of Anaphylaxis (Over 12 wk Period) [MEDLINE]: iron sucrose has lowest risk of all of the intravenous iron agents

Packed Red Blood Cell Transfusion (see Packed Red Blood Cells, [[Packed Red Blood Cells]])

  • Indications
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References

  • Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products. JAMA. 2015 Nov 17;314(19):2062-2068. doi: 10.1001/jama.2015.15572 [MEDLINE]