Epinephrine


Indications

Advanced Cardiac Life Support (ACLS) (see Advanced Cardiac Life Support)

Anaphylaxis (see Anaphylaxis)

Clinical Efficacy

  • xxxx

Asthma (see Asthma)

Clinical Utility

  • Subcutaneous Use in the Setting of Status Asthmaticus is No Longer Recommended

Hemoptysis During Bronchoscopy (see Hemoptysis and Bronchoscopy)

Clinical Efficacy

  • xxxx

Maintenance of Mydriasis During Ocular Surgery

Clinical Efficacy

  • May Be Used for this Indication

Post-Extubation Laryngeal Edema/Stridor (see Stridor)

  • Rationale
    • Results in local vasoconstriction, decreasing laryngeal edema
  • Clinical Efficacy
    • Efficacy is Unclear
    • Pediatric Trial of Dexamthasone and Nebulized Epinephrine in Laryngeal Edema (Int J Pediatr Otorhinolaryngol, 2009) [MEDLINE]: dexamethasone and L-epinephrine did not reduce the clinical progression of airway obstruction due to laryngeal edema in the early post-extubation period

Septic Shock/Hypotension (see Sepsis and Hypotension)

  • Rationale
    • XXXX

Pharmacology

Pharmacologic Effects at Adrenergic Receptors

Pharmacokinetics

Metabolism


Administration

Advanced Cardiac Life Support (ACLS) (see Advanced Cardiac Life Support)

Asystole/Pulseless Electrical Activity (PEA)/Pulseless Ventricular Tachycardia (VT)/Ventricular Fibrillation

Symptomatic Bradycardia (Unresponsive to Atropine and/or Pacing)

Septic Shock/Hypotension (see Sepsis and Hypotension)

Anaphylaxis (see Anaphylaxis)

Post-Extubation Laryngeal Edema/Stridor (see Stridor)

Hemoptysis During Bronchoscopy (see Hemoptysis and Bronchoscopy)

Dose Adjustment

Extravasation Management

Drug Interactions


Adverse Effects

Cardiovascular Adverse Effects

Dermatologic Adverse Effects

Endocrinologic Adverse Effects

Gastrointestinal Aderse Effects

Neurologic Adverse Effects

Pulmonary Adverse Effects

Renal Adverse Effects

Rheumatologic/Orthopedic Adverse Effects


References